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<正>帕金森病(PD)是一种常见的退行性疾病[1]，早期药物治疗效果明显，但长期药物治疗后，逐渐出现疗效减退及运动并发症[2]。脑深部电刺激术(DBS)通过持续的电刺激，弥补药物浓度波动带来的症状波动[3-4]。位于基底核环路的丘脑底核(STN)是治疗PD的最常用靶点核团[5]。据了解，目前尚无双靶点联合DBS手术成功治疗PD合并冻结步态的报道。现报道1例49岁PD合并严重冻结步态患者的双靶点DBS手术治疗及程控策略、临床转归。1病例患者，男性，49岁，工人，因“右侧肢体僵硬、运动迟缓10年，左侧肢体僵硬7年”于2024年4月26日收住院。患者2014年无明显诱因出现右上肢僵硬、迟缓，表现为持筷、系扣子慢;2015年自觉翻身稍困难，逐渐进展，被诊断为PD;2016年发展至右下肢;2017年累及左侧肢体，并出现明显翻身困难，给予美多芭等药物治疗后，尚可生活自理。
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DOI：
中图分类号:R742.5
引用信息:
[1]杨华丹,孙留中,张为等.双侧丘脑底核联合黑质网状部脑深部电刺激术治疗早发型帕金森病冻结步态1例[J].临床神经病学杂志,2025,38(04):275+297-298.
基金信息: