临床神经病学杂志

目的探讨健康管理对颈动脉狭窄患者血脂水平及颈动脉斑块的影响。方法将180例颈动脉狭窄患者分为健康管理组(90例)及常规治疗组(90例)。两组均给予常规治疗,健康管理组进行连续12个月的健康管理。于治疗前及治疗后第6、12个月检测患者的总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋自胆固醇(LDL-C)水平;采用颈动脉彩色多普勒超声检测其颈动脉情况。结果健康管理组及常规治疗组治疗第6、12个月TC、TG、LDL-C水平显著低于治疗前,HDL-C水平显著升高(均P<0.05)。两组间治疗前及治疗第6个月TC、TG、HDL-C及LDL-C水平差异无统计学意义(均P>0.05)。健康管理组治疗第12个月TC、TG及LDL-C水平较常规治疗组显著降低,HDL-C水平显著升高(均P<0.05)。健康管理组及常规治疗组治疗前与治疗第6个月Crouse斑块积分差异无统计学意义(均P>0.05)。健康管理组治疗第12个月Crouse斑块积分显著低于治疗前(均P<0.05)。两组间治疗前及治疗第6个月Crouse斑块积分差异无统计学意义(均P>0.05)。健康管理组治疗第12个月Crouse斑块积分显著低于常规治疗组(P<0.05)。结论长期健康管理干预可以降低颈动脉狭窄患者的血脂水平,改善颈动脉斑块情况。

Objective To explore effect of health management on blood lipid level and carotid artery plaque in patients with carotid artery stenosis. Methods One hundred and eighty patients with carotid artery stenosis were dived divided into health management group( 90 cases) and routine treatment group( 90 cases). All the patients took routine treatment,and the health management were given for 12 months continuously in health management group. The levels of total cholesterol( TC),triglyceride( TG),high density lipoprotein cholesterol( HDL-C) and low density lipoprotein cholesterol( LDL-C) were tested,the carotid artery was checked by carotid artery color Doppler flow imaging before and at 6 months,12 months after treatment. Results The levels of TC,TG,LDL-C in health management group and routine treatment group at 6 and 12 months after treatment were significantly decreased than those before the treatment,and the level of HDL-C were significantly increased( all P < 0. 05). There was no significant difference in the levels of TC,TG,HDL-C,LDL-C before and at 6 months between the two groups( all P > 0. 05). The levels of TC,TG and LDL-C at 12 months after treatment in health management group were significantly decreased than those in routine treatment group,and the level of HDL-C was significantly increased( all P < 0. 05). There was no significant difference in Crouse plaque integral in health management group and routine treatment group between before and at 6 months after treatment( all P > 0. 05). The Crouse plaque integral at 12 months after treatment in health management group and routine treatment group were significantly decreased than those before the treatment( all P < 0. 05). There was no significant difference in Crouse plaque integral before and at 6 months after treatment between the two groups( all P > 0. 05). Crouse plaque integral at 12 months after treatment in health management group was significantly decreased than that in routine treatment group( P < 0. 05). Conclusion Long-term health management can decreased the level of serum lipid level and inflammation,and improve the situation of carotid artery plaque.